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Related Experiment Videos

Foreign bodies in sarcoidosis.

Y C Kim1, M K Triffet, L E Gibson

  • 1Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.

The American Journal of Dermatopathology
|October 26, 2000
PubMed
Summary
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Polarizable foreign bodies are more common in cutaneous sarcoidosis than previously believed. These particles, composed of elements like silicon and aluminum, may trigger granuloma formation in this multisystem disease.

Area of Science:

  • Dermatology
  • Pathology
  • Immunology

Background:

  • Sarcoidosis is a multisystem granulomatous disease of unknown cause.
  • Polarizable foreign bodies in skin granulomas typically rule out sarcoidosis.
  • Some studies suggest sarcoidosis can coexist with foreign bodies in skin lesions.

Purpose of the Study:

  • To determine the frequency of polarizable foreign bodies in cutaneous sarcoidosis.
  • To identify the elemental composition of these foreign bodies.
  • To explore the role of foreign bodies in sarcoidosis pathogenesis.

Main Methods:

  • Polarization microscopy of 50 cutaneous sarcoidosis biopsy specimens.
  • Electron probe microanalysis to identify foreign body elements.
  • Review of systemic lesions in patients with cutaneous sarcoidosis.

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Main Results:

  • Polarizable foreign bodies found in 12 of 50 (24%) cutaneous sarcoidosis lesions.
  • Foreign bodies were also identified in systemic lesions of affected patients.
  • Identified elements included calcium, phosphorus, silicon, and aluminum.

Conclusions:

  • Polarizable foreign bodies are unexpectedly frequent in cutaneous sarcoidosis.
  • These foreign bodies may act as an inciting stimulus for granuloma formation.
  • Findings challenge the traditional view that foreign bodies exclude sarcoidosis.