Related Experiment Video
Updated: Oct 11, 2026

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts
Published on: October 9, 2016
STAT proteins and transcriptional responses to extracellular signals
1Immunobiology Center, Box 1630, East Building Room 12-20D, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. curt.horvath@mssm.edu
Abstract:
Signal transducer and activator of transcription (STAT) transcription factors are implicated in programming gene expression in biological events as diverse as embryonic development, programmed cell death, organogenesis, innate immunity, adaptive immunity and cell growth regulation in organisms ranging from slime molds to insects to man. Rapid progress has unearthed much about the activation of STATs by Janus kinases (JAKs) and other tyrosine kinases and their ability to interface with other signaling systems. Once inside the nucleus, the STATs bind to promoters and join other transcriptional activators in the regulation of gene expression.
Related Concept Videos
Other Stress Responses in Bacteria
The JAK-STAT Signaling Pathway
Stringent Response in E. coli
Global Regulatory Systems
Master Transcription Regulators
Signal Transduction: Overview
Typically, signal transduction involves three...

