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Related Experiment Videos

Carbapenemases: a problem in waiting?

D M Livermore1, N Woodford

  • 1Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, NW9 5HT, London, UK. dlivermore@phls.nhs.uk

Current Opinion in Microbiology
|October 26, 2000
PubMed
Summary
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The emergence of carbapenemase enzymes, particularly metallo-beta-lactamases like IMP-1 and VIM types, poses a growing threat in various bacterial pathogens globally. Understanding these resistance mechanisms is crucial for combating antibiotic resistance.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Carbapenems are broad-spectrum antibiotics crucial for treating resistant bacterial infections.
  • Most beta-lactamases do not degrade carbapenems, but emerging carbapenemases pose a significant threat.
  • Chromosomal carbapenemases are historically limited to specific pathogens.

Purpose of the Study:

  • To investigate the emergence and spread of carbapenemase-producing bacteria.
  • To identify the types and geographical distribution of acquired carbapenemases.
  • To assess the clinical significance of various carbapenemase activities.

Main Methods:

  • Surveillance of bacterial isolates for carbapenemase production.
  • Molecular characterization of identified carbapenemase genes (e.g., IMP, VIM, Class D, Class A).

Related Experiment Videos

  • Evaluation of the impact of carbapenemase activity on antibiotic susceptibility in different bacterial species.

    • Main Results:

    • Acquired metallo-beta-lactamases (e.g., IMP-1, VIM types) are emerging in Pseudomonas aeruginosa, Enterobacteriaceae, and Acinetobacter spp. globally.
    • Class D carbapenemases are increasingly reported in Acinetobacter baumannii worldwide.
    • The level of resistance is influenced by both the carbapenemase potency and bacterial permeability.

    Conclusions:

    • The emergence of diverse carbapenemases represents a significant and growing global health concern.
    • Continued surveillance and characterization of carbapenemase-producing bacteria are essential.
    • The interplay between enzyme activity and bacterial physiology determines the clinical impact of carbapenem resistance.