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Will genomics revolutionize antimicrobial drug discovery?
1Department of Chemotherapy and Molecular Genetics, Schering-Plough Research Institute, 2015 Galloping Hill Road, K-15-4700, Kenilworth, NJ 07974-1300, USA. Todd.Black@spcorp.com
Current Opinion in Microbiology
|October 26, 2000
Summary
Genomic data from pathogens aids antimicrobial discovery, revolutionizing drug development despite no current pipeline drugs. This approach offers significant opportunities and challenges for the pharmaceutical industry.
Area of Science:
- Microbiology
- Genomics
- Drug Discovery
Background:
- Genomic data from bacterial and fungal pathogens is increasingly utilized for novel antimicrobial agent discovery.
- The pharmaceutical and biotechnological sectors show significant interest in this approach.
Purpose of the Study:
- To discuss the application, utility, opportunities, and challenges of using genomics for antimicrobial drug discovery.
Main Methods:
- Analysis of existing genomic sequence data from pathogens.
- Review of current trends and potential future directions in genomics-based drug discovery.
Main Results:
- Genomics has fundamentally changed various aspects of drug discovery.
- No drugs derived from genomics-based discovery are currently in the development pipeline.
Conclusions:
- Genomics presents a powerful, albeit challenging, frontier for discovering new antimicrobial agents.
- Further research and development are needed to translate genomic insights into clinical மருந்துகள்.