Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Experimental muscle diseases.

Methods and Achievements in Experimental Pathology

|January 1, 1975

Summary

This summary is machine-generated.

Skeletal muscle fibers exhibit a stereotyped pathological response to injury, initiating with local coagulative necrosis. Subsequent biological reactions facilitate debris removal and myoblast proliferation for muscle repair.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

TGF-beta1 and TGF-beta2 expression after traumatic human spinal cord injury.

Spinal cord·2007

Same author

Sequential loss of myelin proteins during Wallerian degeneration in the human spinal cord.

Brain : a journal of neurology·2005

Same author

Neuropathology: the foundation for new treatments in spinal cord injury.

Spinal cord·2004

Same author

Prevalence of cerebral vascular amyloid-beta deposition and stroke in an aging Australian population: a postmortem study.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2003

Same author

Retropulsion of intervertebral discs associated with traumatic hyperextension of the cervical spine and absence of vertebral fracture: an uncommon mechanism of spinal cord injury.

Spinal cord·2002

Same author

The mRNA of the NR1 subtype of glutamate receptor in Alzheimer's disease.

Journal of neural transmission (Vienna, Austria : 1996)·2002

Area of Science:

Muscle physiology
Pathology
Regenerative medicine

Background:

Skeletal muscle fiber injury response is extensively studied.
Diverse injury agents induce similar pathological changes.

Purpose of the Study:

To elucidate the stereotyped pathological reaction of skeletal muscle fibers to injury.
To detail the sequence of biological events following muscle fiber necrosis.

Main Methods:

Review of experimental studies on muscle injury.
Analysis of various techniques applied to study muscle pathology.

Main Results:

The primary injury to muscle fibers is local coagulative necrosis.
A consistent series of biological reactions follows necrosis in surviving animals.

Related Experiment Videos

These reactions involve debris removal and myoblast proliferation.

Conclusions:

The pathological response of skeletal muscle fibers to injury is highly stereotyped.
Necrosis is followed by inherent muscle repair mechanisms including debris clearance and regeneration.