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Related Experiment Videos

Radiotherapy for hepatocellular carcinoma.

K Tokuuye1, M Sumi, Y Kagami

  • 1Radiation Oncology Division, National Cancer Center Hospital, Tokyo, Japan. ktokuyne@gan2.ncc.go.jp

Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [Et Al]
|October 29, 2000
PubMed
Summary

Radiotherapy, with or without embolization or ethanol injection, effectively controlled hepatocellular carcinoma and prolonged survival in patients ineligible for surgery. Treatment strategies were individualized based on tumor presentation and liver function.

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Sulfur amino acid levels and related enzyme activities in various brain regions (and other tissues) in normal mice and rolling mice Nagoya.

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Phase I/II study of high-dose rate interstitial radiotherapy for head and neck cancer.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·1992

Area of Science:

  • Hepatobiliary Medicine
  • Radiation Oncology
  • Interventional Radiology

Background:

  • Hepatocellular carcinoma (HCC) poses a significant challenge, particularly for patients unsuitable for surgical resection.
  • Effective non-surgical treatment options are crucial for improving outcomes in this patient population.

Purpose of the Study:

  • To evaluate the efficacy of radiotherapy, alone or combined with transarterial embolization (TAE) and/or percutaneous ethanol injection (PEI), for unresectable HCC.
  • To identify prognostic factors influencing survival and local control in patients treated with these modalities.

Main Methods:

  • Retrospective analysis of 62 patients with unresectable HCC treated between 1984 and 1997.
  • Patients received radiotherapy (50–70 Gy) with or without TAE and/or PEI.

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  • Median follow-up was 8.6 months.

    • Main Results:

    • Overall median survival was 9.5 months.
    • Six-month and 1-year local control rates were 67% and 54%, respectively.
    • Pretreatment liver function, radiation field size, and tumor thrombosis were significant prognostic factors.

    Conclusions:

    • Radiotherapy combined with TAE and/or PEI is an effective strategy for controlling unresectable HCC and extending survival.
    • Personalized treatment approaches, considering tumor characteristics and liver function, are recommended.