New functions from old scaffolds: how nature reengineers enzymes for new functions

Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite.

ACS chemical biology·2016

Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis.

Cell death and differentiation·2012

Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli.

Microbiological research·2008

Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis.

Biochemistry·2001

Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases.

Biochemistry·2001

Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli.

Biochemistry·2001

Regulation of Rho guanine nucleotide exchange factors by G proteins.

Advances in protein chemistry·2007

Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells.

Advances in protein chemistry·2007

Activation of G protein-coupled receptors.

Advances in protein chemistry·2007

Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads.

Advances in protein chemistry·2007

How do receptors activate G proteins?

Advances in protein chemistry·2007

Structural basis of effector regulation and signal termination in heterotrimeric Galpha proteins.

Advances in protein chemistry·2007

AneuGuidederived metal coverage ratio and pore density in Pipeline embolization devices: validation against VasoCT and association with aneurysm occlusion.

Quantitative imaging in medicine and surgery·2026

Synergistic Surface and Interface Regulation of Ultralow-Pt-Loading Cathodes for Low-Alkalinity AEMWEs.

Journal of the American Chemical Society·2026

Chelation-Competition Interface Engineering of Polyphenol-Derived Coordination Polymers for Efficient Emulsion Separation.

Environmental research·2026

Droplet-driven self-powered Pb2 + extraction from industrial wastewater.

Journal of hazardous materials·2026

Steering pH-Dependent Pathways on Unconventional Phase Alloy Nanostructures for Universal Nitrate Electroreduction.

Advanced materials (Deerfield Beach, Fla.)·2026

Solvation-programmed hybrid interphase enables durable aqueous zinc-metal batteries.

Journal of colloid and interface science·2026

Related Experiment Videos

New functions from old scaffolds: how nature reengineers enzymes for new functions

Related Concept Videos

Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite.

Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis.

Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli.

Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis.

Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases.

Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli.

Regulation of Rho guanine nucleotide exchange factors by G proteins.

Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells.

Activation of G protein-coupled receptors.

Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads.

How do receptors activate G proteins?

Structural basis of effector regulation and signal termination in heterotrimeric Galpha proteins.

AneuGuidederived metal coverage ratio and pore density in Pipeline embolization devices: validation against VasoCT and association with aneurysm occlusion.

Synergistic Surface and Interface Regulation of Ultralow-Pt-Loading Cathodes for Low-Alkalinity AEMWEs.

Chelation-Competition Interface Engineering of Polyphenol-Derived Coordination Polymers for Efficient Emulsion Separation.

Droplet-driven self-powered Pb2 + extraction from industrial wastewater.

Steering pH-Dependent Pathways on Unconventional Phase Alloy Nanostructures for Universal Nitrate Electroreduction.

Solvation-programmed hybrid interphase enables durable aqueous zinc-metal batteries.

Related Experiment Videos

New functions from old scaffolds: how nature reengineers enzymes for new functions

Related Concept Videos

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