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Human diadenosine triphosphate hydrolase: preliminary characterisation and comparison with the Fhit protein, a human
A C Asensio1, C R Rodríguez-Ferrer, S Oaknin
1Department of Biochemistry and Molecular Biology, University of La Laguna, Tenerife, Canary Islands, Spain.
Acta Biochimica Polonica
|October 29, 2000
Abstract:
Human platelets diadenosine triphosphatase was characterised and compared with the Fhit protein, a human tumour suppressor with diadenosine triphosphatase activity. Both enzymes exhibit similar Km, are similarly activated by Mg2+, Ca2+ and Mn2+, and inhibited by Zn2+ and suramin. However, they are differentially inhibited by Fhit antibodies and exhibit differences in gel-filtration behaviour.