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Serum zinc levels and Alzheimer's disease
L L Rulon1, J D Robertson, M A Lovell
1Department of Chemistry, University of Kentucky, Lexington 40506-0055, USA.
Biological Trace Element Research
|October 29, 2000
Abstract:
Concentrations of zinc in postmortem serum and four brain regions were measured by flame atomic absorption spectrometry and instrumental neutron activation analysis, respectively, in nine Alzheimer's disease (AD) and eight control subjects. A statistically significant elevation of zinc serum was observed in AD subjects (136.4+/-66.8 microg/dL) compared with age-matched control subjects (71.1+/-35.0 microg/dL). No significant differences were observed between AD and control zinc concentrations in the amygdala, hippocampus, cerebellum, and superior and middle temporal gryi.