Related Experiment Video

Updated: Jul 29, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

[Some pathogenetic mechanisms of bacterial bronchial asthma in paecilomycosis]

A M Akhunova

    Klinicheskaia Meditsina
    |October 29, 2000
    PubMed

    Insights

    Paecilomyces fungi can cause bacterial asthma by triggering IgE-mediated hypersensitivity and releasing phospholipase A2. Immune system resistance influences the clinical course and outcomes of this fungal infection.

    Area of Science:

    • Mycology
    • Immunology
    • Pulmonology

    Context:

    • Bronchial asthma is a chronic respiratory condition.
    • Fungal infections can exacerbate or trigger asthma symptoms.
    • Paecilomyces species are increasingly recognized as potential pathogens.

    Purpose:

    • To investigate the role of Paecilomyces fungi in the development of bacterial asthma.
    • To analyze the immunological mechanisms involved in Paecilomyces-induced asthma.
    • To evaluate the clinical characteristics, course, and outcomes of bacterial asthma in patients with Paecilomyces infection.

    Summary:

    • A study analyzed 190 patients (3-70 years) with bronchial asthma and Paecilomyces infection over a 2-week to 18-year follow-up.
    • Paecilomyces fungi act as a specific agent causing bacterial asthma, involving IgE-mediated hypersensitivity and phospholipase A2.
    • Asthma outcomes depend on the host's immune resistance to hematogenic fungal infection and agent elimination.

    Impact:

    • Highlights Paecilomyces as a specific cause of bacterial asthma.
    • Elucidates the immunological pathways (IgE, phospholipase A2) in fungal-induced asthma.
    • Emphasizes the importance of immune status in managing fungal asthma complications.

    More Related Videos

    The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice12:27

    The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice

    Published on: April 2, 2014

    A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice07:43

    A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice

    Published on: September 28, 2016

    Related Concept Videos

    Asthma: Pathogenesis and Management01:20

    Asthma: Pathogenesis and Management

    Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
    Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
    Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

    Chronic Obstructive Pulmonary Disease-II: Pathophysiology

    Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
    Chronic Inflammation
    Asthma-II: Pathophysiology and Classification01:26

    Asthma-II: Pathophysiology and Classification

    Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
    Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
    Critical processes in asthma pathophysiology include:
    Atypical Pneumonia01:14

    Atypical Pneumonia

    Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
    Asthma I: Introduction01:28

    Asthma I: Introduction

    Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
    Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

    Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

    Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...