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Acute hepatitis induced by bupropion.

K Q Hu¹, L Tiyyagura, G Kanel

¹Department of Pathology, University of Southern California School of Medicine, Downey, USA.

Digestive Diseases and Sciences

|October 29, 2000

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Bupropion, an antidepressant, can rarely cause acute hepatitis. This case highlights a severe reaction with elevated liver enzymes, resolving after bupropion discontinuation.

Area of Science:

Hepatology
Pharmacology
Clinical Medicine

Background:

Bupropion is an antidepressant generally considered safe with rare, mild liver enzyme elevations.
Previous reports of bupropion-associated liver injury are infrequent and typically asymptomatic.

Observation:

A patient presented with acute hepatitis symptoms after six weeks of bupropion treatment.
Significant elevations in ALT, AST, and LDH indicated acute hepatic inflammation.

Findings:

The patient's clinical course and liver enzyme profile mimicked a previously reported case but were more severe.
Discontinuation of bupropion led to rapid resolution of symptoms and liver enzymes.

Implications:

Bupropion-induced hepatitis, though rare, is a potential clinical entity.

Related Experiment Videos

Awareness of this adverse effect is crucial given bupropion's widespread use.