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Related Experiment Videos

Acute hepatitis induced by bupropion.

K Q Hu1, L Tiyyagura, G Kanel

  • 1Department of Pathology, University of Southern California School of Medicine, Downey, USA.

Digestive Diseases and Sciences
|October 29, 2000
PubMed
Summary

Bupropion, an antidepressant, can rarely cause acute hepatitis. This case highlights a severe reaction with elevated liver enzymes, resolving after bupropion discontinuation.

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Area of Science:

  • Hepatology
  • Pharmacology
  • Clinical Medicine

Background:

  • Bupropion is an antidepressant generally considered safe with rare, mild liver enzyme elevations.
  • Previous reports of bupropion-associated liver injury are infrequent and typically asymptomatic.

Observation:

  • A patient presented with acute hepatitis symptoms after six weeks of bupropion treatment.
  • Significant elevations in ALT, AST, and LDH indicated acute hepatic inflammation.

Findings:

  • The patient's clinical course and liver enzyme profile mimicked a previously reported case but were more severe.
  • Discontinuation of bupropion led to rapid resolution of symptoms and liver enzymes.

Implications:

  • Bupropion-induced hepatitis, though rare, is a potential clinical entity.
  • Awareness of this adverse effect is crucial given bupropion's widespread use.

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