Related Experiment Video
Updated: Oct 10, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Transmission of viral respiratory infections in the home
1Department of Medicine Children's Hospital, Boston, MA 02115, USA. Don.Goldmann@TCH.harvard.edu
Abstract:
Respiratory viruses in the home exploit multiple modes of transmission. RSV is transmitted primarily by contact with ill children and contaminated objects in the environment. Influenza appears to be spread mainly by airborne droplet nuclei. Despite many years of study, from the plains of Salisbury, to the hills of Virginia, to the collegiate environment of Madison, WI, the precise routes rhinovirus takes to inflict the misery of the common cold on a susceptible population remain controversial.
Insights
Respiratory viruses spread through homes via different routes. Respiratory Syncytial Virus (RSV) spreads by contact, while influenza uses airborne droplets, but rhinovirus transmission remains debated.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Respiratory viruses are a significant cause of illness.
- Understanding transmission routes is crucial for control.
- Different viruses utilize distinct methods for spread.
Purpose of the Study:
- To review and discuss the transmission routes of common respiratory viruses.
- To highlight the established and controversial modes of viral spread in household settings.
Main Methods:
- Review of existing literature on respiratory virus transmission.
- Comparative analysis of transmission pathways for RSV, influenza, and rhinovirus.
Main Results:
- Respiratory Syncytial Virus (RSV) primarily spreads through direct contact with infected individuals or contaminated surfaces.
- Influenza virus transmission is mainly attributed to airborne droplet nuclei.
- The exact transmission routes for rhinovirus, the common cold virus, are still under investigation and subject to debate.
Conclusions:
- Household respiratory virus transmission is multifactorial.
- Established routes for RSV and influenza contrast with the ongoing uncertainty surrounding rhinovirus.
- Further research is needed to definitively elucidate rhinovirus transmission dynamics.
Related Concept Videos
Respiratory Syncytial Virus Disease
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Influenza
Transmission of Pathogens
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
