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Lactoferrin in infant formulas: effect on oxidation.

M T Satué-Gracia1, E N Frankel, N Rangavajhyala

  • 1Department of Food Science and Technology, University of California, Davis, California 95616, USA.

Journal of Agricultural and Food Chemistry
|October 29, 2000
PubMed
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Lactoferrin, an iron-binding protein, acts as an antioxidant in infant formula. It protects against lipid oxidation, even at high iron levels, offering dual antioxidant and antimicrobial benefits.

Area of Science:

  • Food Science
  • Biochemistry
  • Nutritional Science

Background:

  • Lactoferrin, an iron transport protein in human milk, is present at lower levels in cow's milk-based infant formula and absent in soy-based formulas.
  • Infant formulas are supplemented with significant amounts of iron, potentially increasing lipid oxidation.
  • Lactoferrin possesses known bacteriostatic and bactericidal properties.

Purpose of the Study:

  • To investigate the antioxidant effects of lactoferrin in infant formulas.
  • To determine if lactoferrin's antioxidant activity is influenced by supplemental iron concentrations.
  • To evaluate lactoferrin as a potential dual-purpose additive for infant nutrition.

Main Methods:

  • Two infant formulas (cow's milk-based and soy-based) were used.

Related Experiment Videos

  • Varying concentrations of lactoferrin and supplemental iron were added.
  • Lipid oxidation was assessed by measuring hydroperoxide formation, hexanal production, and fluorescence over time.

    • Main Results:

    • Lactoferrin demonstrated significant antioxidant activity in both infant formulas, reducing lipid oxidation.
    • This antioxidant effect was concentration-dependent and persisted even at iron concentrations exceeding lactoferrin's binding capacity.
    • Lactoferrin inhibited oxidation in the presence of supplemental iron.

    Conclusions:

    • Lactoferrin effectively inhibits lipid oxidation in infant formulas, acting as a potent antioxidant.
    • Its antioxidant properties are independent of its iron-binding capacity at higher concentrations.
    • Lactoferrin is a promising additive for infant formulas, providing both antioxidant and antimicrobial benefits.