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Renal acidification in hypothyroid man.

J R Oster, U F Michael, G O Perez

    Clinical Nephrology
    |September 1, 1976
    PubMed
    Summary
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    Thyroid hormone deficiency may impair kidney function, leading to incomplete distal renal tubular acidosis in some hypothyroid patients. This condition affects the kidney's ability to secrete hydrogen ions.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Renal Physiology

    Background:

    • The function of thyroid hormone in renal hydrogen ion secretion is not well understood.
    • Limited data exists on renal acidification in patients with hypothyroidism.

    Purpose of the Study:

    • To investigate the role of thyroid hormone in renal acidification.
    • To assess renal hydrogen ion secretion in hypothyroid patients.

    Main Methods:

    • Studied five adult male patients with untreated primary hypothyroidism.
    • Administered a short-duration acid-loading test.
    • Monitored urine pH and urinary bicarbonate excretion.
    • Assessed arterial blood gas values.

    Main Results:

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    • Two out of five patients demonstrated an impaired ability to lower urine pH post-acid-loading.
    • Arterial blood gas values were normal before acid-loading.
    • Urinary bicarbonate excretion was minimal in affected patients.

    Conclusions:

    • Findings suggest an incomplete syndrome of distal renal tubular acidosis in some hypothyroid patients.
    • Thyroxine deficiency may contribute to this renal acidification defect.
    • The precise mechanism requires further investigation.