Mechanisms of tissue injury in systemic lupus erythematosus

SLE is a syndrome with protean clinical manifestation, a diversity of immunologic abnormalities, and a host of potential etiologic agents. In recent years, considerable information has been accumulated concerning the immunopathogenesis of SLE, and significant advances have been made in the treatment of the disease by utilizing immunosuppressive therapy. Further investigation will be needed to clarify the mechanisms of tissue injury, especially as they relate to the CNS, and to identify the factors responsible for initiating the SLE syndrome.