Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A spatial frequency-doubling illusion-based pattern electroretinogram for glaucoma.

T Maddess1, A C James, I Goldberg

  • 1Centre for Visual Sciences, Research School of Biological Sciences, Australian National University, Canberra. Prince of Wales Hospital, Sydney, Australia. ted.maddess@anu.edu.au

Investigative Ophthalmology & Visual Science
|October 29, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hazy Blue Worlds: A Holistic Aerosol Model for Uranus and Neptune, Including Dark Spots.

Journal of geophysical research. Planets·2022
Same author

Context Matters: Social Psychological Factors That Underlie Academic Performance across Seven Institutions.

CBE life sciences education·2021
Same author

Learning complex texture discrimination.

Journal of the Optical Society of America. A, Optics, image science, and vision·2021
Same author

Dermoscopy of blastic plasmacytoid dendritic cell neoplasm in two patients.

Clinical and experimental dermatology·2021
Same author

Symptomatic mucosal involvement in pachyonychia congenita: challenges in infants and young children.

The British journal of dermatology·2019
Same author

Nested case-control study investigating the diagnostic role of tissue eosinophilia in adverse cutaneous drug reactions.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same journal

Impact of Subretinal Drusenoid Deposits on Ellipsoid Zone-Related Thickness Metrics.

Investigative ophthalmology & visual science·2026
Same journal

Proteomic Profiling of Optic Nerves From SMOX-Deficient Mice Identifies Regulators of Neuroinflammation and Axonal Damage in Optic Neuritis.

Investigative ophthalmology & visual science·2026
Same journal

Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function.

Investigative ophthalmology & visual science·2026
Same journal

Spatial Decomposition of Longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure-Function and Genetic Signatures.

Investigative ophthalmology & visual science·2026
Same journal

The CXXC1-IGFBP6 Axis Maintains Corneal Epithelial Differentiation via H3K4me3-Dependent Transcriptional Activation.

Investigative ophthalmology & visual science·2026
Same journal

Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery.

Investigative ophthalmology & visual science·2026
See all related articles

The multiregion frequency-doubling pattern electroretinogram (MFP) shows high accuracy in diagnosing glaucoma. This novel method offers significant value for early glaucoma detection and management.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Visual Science

Background:

  • Glaucoma diagnosis relies on detecting optic nerve damage.
  • Early detection is crucial for preventing vision loss.
  • Pattern electroretinogram (PERG) is an established diagnostic tool.

Purpose of the Study:

  • To evaluate the efficacy of a novel multiregion frequency-doubling (FD) PERG (MFP) for glaucoma diagnosis.
  • To assess the sensitivity and specificity of the MFP method.

Main Methods:

  • Utilized nine stimulus regions with temporally modulated incommensurate frequencies to induce FD percept.
  • Investigated two different spatial scales of stimuli.
  • Employed linear and quadratic discriminant methods to analyze MFP data.

Related Experiment Videos

Main Results:

  • Achieved 100% sensitivity and specificity in diagnosing moderate to severe glaucoma using linear discriminant analysis.
  • Classified 67% of suspected glaucoma cases as glaucomatous.
  • Observed varying PERG visual field dependencies based on stimulus spatial scales.

Conclusions:

  • The MFP method demonstrates significant potential for glaucoma diagnosis.
  • Different spatial scales may access distinct neural mechanisms.
  • MFP offers a valuable tool for identifying glaucoma, even in early stages.