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Updated: Oct 10, 2026
Crystallization of Membrane Proteins in Lipidic Mesophases
Published on: March 28, 2011
Crystallization and preliminary X-ray analysis of CTLA-4 (CD152) membrane-external domain
C Y Chang1, W H Fenderson, T B Lavoie
1Macromolecular Structure, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA.
Abstract:
CTLA-4 (CD152) is involved in T-lymphocyte co-stimulatory pathways modulating both humoral and cellular immune response. The membrane-external domain has been prepared and crystallized. The unit-cell parameters are a = b = 43, c = 143 A with the symmetry of space group P3(1)21 or its enantiomer and the crystals diffract to 2. 7 A resolution at synchrotron beamlines.
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