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Updated: Aug 11, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 27, 2013
Th1 and Th2 cytokines in a patient with Evans' syndrome and profound lymphopenia
M Karakantza1, A Mouzaki, M Theodoropoulou
1Laboratory of Haematology and Transfusion Medicine, Department of Medicine, School of Health Sciences, University of Patras, Patras, Greece. makara@med.upatras.gr
Abstract:
A case of Evans' syndrome with IgM deficiency and lymphopenia was studied before and after splenectomy. The lymphopenia was as a result of profound reduction of CD4 and CD8 cells. Study of cytokine secretion before splenectomy revealed a spontaneous Th1- and Th2-type cytokine production, and complete suppression of transforming growth factor (TGF)-beta. After splenectomy, the patient achieved clinical remission, the natural killer (NK) cell number increased and the pattern of cytokine production showed normalization of interleukin (IL)-2, IL-4, IL-10, TGF-beta and abolition of interferon (IFN)-gamma production. We conclude that splenectomy had a beneficial effect owing to an increase in NK cells and an associated increase in TGF-beta production.
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