Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

vCJD - predicting the future?

D A Hilton1

  • 1Department of Histopathology, Derriford Hospital, Plymouth, UK. david.hilton@phnt.swest.nhs.uk

Neuropathology and Applied Neurobiology
|October 29, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cellular prion protein (PrP<sup>C</sup>) in the development of Merlin-deficient tumours.

Oncogene·2017
Same author

Changing molecular profile of brain metastases compared with matched breast primary cancers and impact on clinical outcomes.

British journal of cancer·2016
Same author

A tale of the unexpected: Amyloidoma associated with intracerebral lymphoplasmacytic lymphoma.

Journal of the neurological sciences·2015
Same author

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival.

Oncogene·2013
Same author

Macrophagic myofasciitis: a report of second case from UK.

Neuropathology and applied neurobiology·2012
Same author

Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival.

Oncogene·2011
Same journal

Diagnostic Alteration Is Not Therapeutic Dependency: Lessons From Failed RET Inhibition in a PLAG-Altered CNS Embryonal Tumour.

Neuropathology and applied neurobiology·2026
Same journal

Respone to Škudar.

Neuropathology and applied neurobiology·2026
Same journal

Unravelling the Significance of Cystatin C and Bunina Bodies in Amyotrophic Lateral Sclerosis Pathogenesis.

Neuropathology and applied neurobiology·2026
Same journal

Neuropathological and Molecular Features Associated With a Heterozygous DNAJC7 Mutation in Amyotrophic Lateral Sclerosis.

Neuropathology and applied neurobiology·2026
Same journal

Central Nervous System Embryonal Tumour With PLAGL Amplification Lacking Typical Embryonal Morphology: Diagnostic Pitfall in a Paediatric Case.

Neuropathology and applied neurobiology·2026
Same journal

Lewy Bodies Are Not Associated With Neuronal or Synaptic Loss in Dementia With Lewy Bodies.

Neuropathology and applied neurobiology·2026
See all related articles

Concerns about variant Creutzfeldt-Jakob disease (vCJD) spread are high due to bovine spongiform encephalopathy (BSE) link. Studies examine PrPSc accumulation in tissues to predict future vCJD cases and epidemic potential.

Area of Science:

  • Neuroscience
  • Epidemiology
  • Pathology

Background:

  • Variant Creutzfeldt-Jakob disease (vCJD) linked to bovine spongiform encephalopathy (BSE) prions raises epidemic concerns.
  • Uncertainty exists regarding vCJD incubation periods and future case numbers.
  • Prion protein (PrPSc) accumulation in lymphoreticular tissues is a potential early marker for vCJD.

Purpose of the Study:

  • To assess the potential for a large human vCJD epidemic.
  • To investigate the utility of lymphoreticular PrPSc accumulation as an early indicator of vCJD.
  • To inform predictions of future vCJD case numbers.

Main Methods:

  • Analysis of PrPSc accumulation in surgically removed tonsillectomy and appendicectomy specimens.
  • Monitoring lymphoreticular PrPSc presence in large-scale, anonymous studies.

Related Experiment Videos

  • Utilizing animal models of prion disease to understand disease progression.

    • Main Results:

    • Extensive lymphoreticular PrPSc accumulation observed in all symptomatic vCJD cases examined.
    • PrPSc detected in one case 8 months before symptom onset.
    • Initial examination of 3000 specimens revealed no positive PrP accumulation findings.

    Conclusions:

    • Lymphoreticular PrPSc accumulation appears early in vCJD and may predict neurological disease.
    • Ongoing studies aim to clarify the significance of negative findings and the timing of PrPSc detection.
    • Further data will help assess the likelihood of a widespread human vCJD epidemic.