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Massive sertraline overdose.

D H Brendel1, J A Bodkin, J M Yang

  • 1Departments of Psychiatry and Laboratory Medicine, Massachusetts General Hospital, Boston, MA 02114-2698, USA.

Annals of Emergency Medicine
|October 29, 2000
PubMed
Summary
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Selective serotonin reuptake inhibitors (SSRIs) are generally safe in overdose. This case details a massive sertraline overdose, potentially causing serotonin syndrome with symptoms like confusion and fever.

Area of Science:

  • Pharmacology
  • Clinical Toxicology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed antidepressants.
  • SSRIs are generally considered to have a good safety profile, even in overdose scenarios.

Observation:

  • A massive overdose of sertraline was reported.
  • The patient presented with confusion, agitation, myoclonus, hyperreflexia, fever, and elevated creatine kinase.

Findings:

  • The serum sertraline concentration in this case was the highest ever reported.
  • The clinical presentation suggests serotonin syndrome potentially caused by sertraline overdose alone.

Implications:

  • This case highlights the potential for severe toxicity from massive SSRI overdoses.

Related Experiment Videos

  • Clinicians should be aware of the possibility of serotonin syndrome in patients with significant sertraline exposure.
  • Further research may be warranted to define the upper safety limits of sertraline.