[Sequential chemotherapy based on the hypothesis of a circadian rhythm of tumor proliferation]

The authors treated 41 cases of advanced solid tumors by a combination chemotherapy with methotrexate, vinblastine and cyclophosphamide administered in a sequential manner according to the hypothesis of a circadiam rhythm of proliferation of human neoplasia. A tumoral regression was observed in 66. 6 p. cent of adenocarcinomas and 86.2 p.cent of non glandular carcinomas.