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Chronic multiple paraneoplastic syndromes
K A Kleopa1, J W Teener, S S Scherer
1Department of Neurology, 3 West Gates, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania 19104-4283, USA. kleopa@mail.med.upenn.edu
Abstract:
A patient presented with symptoms of limbic and brainstem encephalitis, motor and sensory neuronopathy, cerebellar dysfunction, and highly positive anti-Hu antibodies. He also harbored P/Q-type calcium channel antibodies and manifested the Lambert-Eaton myasthenic syndrome (LEMS). Small-cell lung cancer was found, and he received both antineoplastic therapy and intravenous immunoglobulin (IVIg). Remission of the malignancy was achieved. Although the anti-Hu-related manifestations improved after therapy, LEMS has persisted, leading to IVIg dependency.