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Hyperbaric oxygen therapy and the diabetic foot.

D J Bakker1

  • 1Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. d.j.bakker@amc.uva.nl

Diabetes/Metabolism Research and Reviews
|October 31, 2000
PubMed
Summary

Hyperbaric oxygen therapy (HBOT) may improve healing for diabetic foot ulcers by increasing oxygen levels and enhancing immune function. Further rigorous clinical trials are needed to confirm its effectiveness as a standard treatment.

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Area of Science:

  • Wound Healing
  • Hyperbaric Medicine
  • Diabetic Complications

Background:

  • Diabetic foot ulcers often fail to heal due to infection and ischemia, compounded by impaired immune responses in diabetic patients.
  • Diabetes mellitus compromises cellular and humoral immunity, affecting leukocyte function and inflammatory responses crucial for wound repair.
  • Oxygen is vital for wound healing, and hyperbaric oxygen therapy (HBOT) can elevate tissue oxygen levels.

Purpose of the Study:

  • To discuss the potential benefits of hyperbaric oxygen therapy (HBOT) as an adjunct treatment for diabetic foot ulcers.
  • To review existing evidence, including anecdotal reports, retrospective, and prospective studies on HBOT for diabetic wounds.

Main Methods:

  • Review of literature on the role of oxygen in wound healing and the effects of HBOT on diabetic patients with foot ulcers.

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  • Discussion of HBOT's mechanisms, including increased tissue oxygenation, enhanced leukocyte activity, and antimicrobial effects against anaerobes.

    • Main Results:

    • Existing studies suggest HBOT may be beneficial for managing diabetic foot wounds.
    • Anecdotal reports and some prospective studies indicate positive outcomes with HBOT.
    • Methodological limitations in current studies necessitate further investigation.

    Conclusions:

    • Hyperbaric oxygen therapy (HBOT) shows promise as an adjunctive therapy for diabetic foot ulcers.
    • There is a critical need for high-quality, international, randomized controlled trials to establish HBOT as a standard treatment.
    • A multidisciplinary approach is essential for managing diabetic foot lesions effectively.