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Related Experiment Videos

Computerized system for outcomes-based antiemetic therapy in children.

M T Holdsworth1, V R Adams, D W Raisch

  • 1College of Pharmacy, University of New Mexico, Albuquerque 87131, USA. markt@unm.edu

The Annals of Pharmacotherapy
|October 31, 2000
PubMed
Summary

A new computerized system efficiently collects antiemetic therapy data in children. The daily ondansetron and dexamethasone (OD) regimen offers superior, cost-effective control of chemotherapy-induced nausea and vomiting.

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Area of Science:

  • Pediatric Oncology
  • Clinical Pharmacology
  • Health Informatics

Background:

  • Chemotherapy often causes significant nausea and vomiting in children.
  • Effective antiemetic therapy is crucial for maintaining treatment adherence and quality of life.
  • Outcomes-based approaches require efficient and accurate data collection.

Purpose of the Study:

  • To introduce a computerized data collection system for antiemetic therapy outcomes in pediatric oncology.
  • To present data supporting a new antiemetic dosing regimen (OD) using this system.
  • To compare the efficiency and effectiveness of the new system and regimen against traditional methods.

Main Methods:

  • A validated nausea/vomiting survey was administered via handheld devices.

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  • Data collected included nausea severity, vomiting severity, activity interference, and vomiting episodes.
  • Time and motion studies compared manual versus computerized data entry.
  • The computerized system collected data for a new regimen (daily ondansetron and dexamethasone [OD]) versus an older regimen (OM).

    • Main Results:

    • Computerized data entry was significantly faster (2.4 vs. 5.2 minutes; p=0.0026).
    • The OD regimen showed significantly lower nausea/vomiting scores (NSEV, VSEV, DAI) and fewer vomiting episodes compared to OM (p<0.05).
    • Complete (39.2% vs. 19.2%) and good (65.4% vs. 55.6%) control rates were significantly higher with OD (p<0.05).
    • Cost-effectiveness analysis indicated OD was cheaper per patient for both good and complete protection.

    Conclusions:

    • A computerized, handheld system enhances the efficiency of collecting antiemetic therapy outcomes data.
    • The daily ondansetron and dexamethasone (OD) regimen is a more effective and cost-effective option for pediatric patients receiving highly emetogenic chemotherapy.