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Olanzapine-induced acute pancreatitis
D E Doucette1, J P Grenier, P S Robertson
1Pharmaceutical Services, Royal Alexandra Hospital, Capital Health Authority, Edmonton, Alberta, Canada. doucette@planet.eon.net
The Annals of Pharmacotherapy
|October 31, 2000
Summary
This case report details the first suspected instance of olanzapine, an atypical antipsychotic, causing acute pancreatitis. The patient, an elderly woman, developed severe pancreatitis after starting olanzapine, leading to her death.
Area of Science:
- Pharmacology
- Gastroenterology
- Clinical Toxicology
Background:
- Acute pancreatitis is a serious condition with various potential causes.
- Olanzapine is an atypical antipsychotic medication used for psychiatric conditions.
Observation:
- A 72-year-old female developed acute hemorrhagic pancreatitis six days after initiating olanzapine.
- The patient had no history of alcohol abuse or gallstones, and other causes of pancreatitis were excluded.
Findings:
- Olanzapine was identified as the probable cause of acute pancreatitis based on the Naranjo probability scale.
- This represents the first documented case report linking olanzapine to acute pancreatitis.
Implications:
- Clinicians should be aware of the potential for olanzapine to induce pancreatitis.
- Further research is needed to elucidate the mechanism of olanzapine-induced pancreatitis.