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Treatment of chronic hepatitis C virus infection

S D Malnick1, M Beergabel, Y Lurie

  • 1Department of Internal Medicine C, Kaplan Medical Center, Rehovot Israel. stevash@trendline.co.il

The Annals of Pharmacotherapy
|October 31, 2000
PubMed

Insights

Treatment for chronic hepatitis C virus (HCV) infection has advanced significantly. Combination therapy with interferon and ribavirin offers higher response rates than interferon alone, improving cure rates for this public health issue.

Area of Science:

  • Hepatology
  • Virology
  • Internal Medicine

Background:

  • Chronic hepatitis C virus (HCV) infection presents a significant global health challenge.
  • Early treatment strategies for HCV were limited in efficacy.

Purpose of the Study:

  • To conduct a comprehensive literature review on the treatment of chronic hepatitis C virus (HCV) infection.
  • To evaluate the effectiveness of various therapeutic interventions for HCV.

Main Methods:

  • A MEDLINE database search was performed from 1986 to December 1999.
  • Keywords included "HCV," "hepatitis," "non-A and non-B hepatitis," and treatment-related terms.

Main Results:

  • Interferon monotherapy yielded limited long-term responses in HCV patients.
  • Combination therapy with interferon and ribavirin demonstrated higher response rates in both treatment-naïve and relapsed patients.
  • Alternative treatments like high-dose interferon, ursodeoxycholic acid, amantadine, and NSAIDs showed less promise, with ongoing investigation into novel therapies.

Conclusions:

  • HCV infection remains a major public health concern requiring effective treatment strategies.
  • Current therapeutic advancements allow for achieving a cure in approximately 50% of patients.
  • Ongoing research and evaluation of additional therapies are crucial for improving HCV cure rates.
Abstract

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