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Synthetic biodegradable polymers as orthopedic devices.

J C Middleton¹, A J Tipton

¹Birmingham Polymers, Inc., AL 35211, USA. jmiddleton@bpi-sbs.com

|October 31, 2000

Summary

Biodegradable polymers like poly(lactides) and poly(glycolides) offer ideal properties for orthopedic implants when permanent devices are not needed. Their synthesis, degradation, and biocompatibility are key for medical applications.

Area of Science:

Biomaterials Science
Polymer Chemistry
Orthopedic Surgery

Background:

Significant advances in synthetic materials for medical use over 30 years.
Focus on biodegradable polymers for orthopedic applications where permanent implants are undesirable.

Purpose of the Study:

Detail properties of biodegradable polymers for orthopedic use.
Discuss poly(lactides) and poly(glycolides) in depth.
Cover chemistry, processing, and biocompatibility.

Main Methods:

Review of polymer chemistry, including synthesis and degradation.
Analysis of property tailoring via synthetic controls (e.g., copolymer composition).
Examination of processing, handling, and biodegradation mechanisms.

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Main Results:

Poly(lactides) and poly(glycolides) are established biodegradable polymers for orthopedic applications.
Properties can be tailored through copolymer composition and synthetic controls.
Understanding degradation mechanisms is crucial for device performance.

Conclusions:

Biodegradable polymers, particularly poly(lactides) and poly(glycolides), are highly suitable for orthopedic implants.
Careful control over synthesis, processing, and understanding degradation are essential for successful clinical translation.
Biocompatibility and specific orthopedic device applications are reviewed.