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Published on: October 29, 2014
Yersinia enterocolitica infection in children
N M Abdel-Haq1, B I Asmar, W M Abuhammour
1Wayne State University School of Medicine and Children's Hospital of Michigan, Detroit 48201, USA.
Insights
Yersinia enterocolitica causes enteritis in young children, particularly during winter. Exposure to chitterlings is a risk factor, and infants under 3 months face higher bacteremia risk.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Gastroenterology
Background:
- Yersinia enterocolitica infection presents a spectrum from mild enteritis to severe systemic illness in children.
- Understanding the epidemiology and clinical course of Y. enterocolitica enteritis in pediatric populations is crucial for effective management.
Purpose of the Study:
- To review the epidemiology, clinical manifestations, complications, and outcomes of Yersinia enterocolitica enteritis in children.
- To identify risk factors and assess treatment efficacy for Y. enterocolitica infections in a pediatric cohort.
Main Methods:
- Retrospective chart review of medical and microbiologic records.
- Analysis of stool cultures positive for Y. enterocolitica over a 7-year period in a large children's hospital.
- Evaluation of patient demographics, clinical presentations, treatment responses, and outcomes.
Main Results:
- 142 pediatric cases of Y. enterocolitica enteritis were identified, with 85% of patients under 1 year old.
- Infections peaked during November, December, and January, with chitterling exposure noted as a significant risk factor.
- Bacteremia occurred in 9% of patients, predominantly in infants under 1 year; cefotaxime showed effectiveness in treating bacteremic cases.
Conclusions:
- Yersinia enterocolitica is a significant cause of pediatric enteritis, especially during winter months, with chitterling exposure a key risk factor.
- Infants under 3 months are at higher risk for developing Yersinia enterocolitica bacteremia.
- Cefotaxime is effective for Y. enterocolitica bacteremia, but the role of oral antibiotics for enteritis requires further investigation.
Background:
Yersinia enterocolitica can cause illness ranging from self-limited enteritis to life-threatening systemic infection. The present study was undertaken to review the epidemiology, clinical manifestations, complications and outcome of Y. enterocolitica enteritis in children seen at a large children's hospital.
Methods:
The project consisted of a retrospective chart review of medical and microbiologic records of all children with stool cultures positive for Y. enterocolitica during a 7-year period.
Results:
The review included 142 patients with Y. enterocolitica enteritis. Patients' ages ranged from 18 days to 12 years, and the majority (85%) were younger than 1 year. Most patients presented during November, December and January. History of exposure to chitterlings (raw pork intestines) at home was elicited in 25 of 30 cases. Y. enterocolitica accounted for 12.6% (142 of 1,120) of all bacterial intestinal pathogens isolated during the study period. Blood cultures were positive in 7(9%) of 78 patients; 6 were younger than 1 year and one 12-year-old had sickle cell disease. Of 132 isolates tested all were susceptible to trimethoprim-sulfamethoxazole, tobramycin and gentamicin; the majority were susceptible to cefotaxime (99%), ceftazidime (89%) and cefuroxime (88%). All bacteremic patients responded to cefotaxime treatment. Follow-up evaluation of 40 ambulatory patients revealed no difference in clinical improvement between those treated with oral trimethoprim-sulfamethoxazole (17 of 23) and those who were not treated (8 of 17) (P = 0.1).
Conclusion:
Y. enterocolitica is an important cause of enteritis in our young patient population during the winter holidays. Exposure of infants to chitterlings appears to be a risk factor. Infants younger than 3 months are at increased risk for bacteremia. Cefotaxime is effective in the treatment of Y. enterocolitica bacteremia; however, the role of oral antibiotics in the management of enteritis needs further evaluation.
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