Related Experiment Videos
Mediastinal plasma cell tumor in a sheep
1Departamento de Anatomía y Anatomía Patológica Comparadas, Universitario de Rabanales, Ctra. Madrid-Cádiz, Córdoba, Spain. an1pearj@uco.es
Veterinary Pathology
|October 31, 2000
Summary
This study reports the first case of extramedullary plasmacytoma in a sheep, a tumor found in the mediastinum with lung and portal vein metastasis. The tumor was diagnosed using cytologic and histopathologic analyses.
Area of Science:
- Veterinary Pathology
- Oncology
Background:
- Extramedullary plasmacytomas are rare neoplasms of plasma cells that can occur outside of bone marrow.
- Sheep are not a commonly reported species for plasmacytoma development.
Observation:
- A 10-year-old sheep presented with a large mediastinal mass (25x15x10 cm).
- Metastases were identified in the lungs (0.5-2 cm nodules) and portal vein (10 cm mass).
- Cytologic and histopathologic findings confirmed a moderately differentiated plasmacytoma.
Findings:
- Immunophenotyping revealed tumor cells expressing lambda light chain IgG+, CD79a-, and CD3-.
- Corynebacterium was isolated from granulomas at the tumor periphery.
- The tumor likely originated in mediastinal lymph nodes.
Implications:
- This case represents the first documented instance of extramedullary plasmacytoma in sheep.
- Highlights the importance of considering plasmacytoma in sheep with mediastinal masses and metastatic disease.
- The presence of Corynebacterium suggests a potential role in tumor-associated inflammation or secondary infection.