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Primary habitual abortions are associated with high frequency of factor V Leiden mutation
M L Wramsby1, M Sten-Linder, K Bremme
1Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden. margaretha.wramsby@kbh.ki.se
Objective:
To analyze the prevalence of the mutation G1691A in factor V gene (Leiden mutation), of mutation C677T in the methylenetetrahydrofolate reductase (MTHFR) gene, and of polymorphism in G20210A in the prothrombin gene in women with recurrent abortions; further, to identify a subgroup at higher risk of being carriers of these mutations.
Design:
Prospective case control evaluation.
Setting:
University clinic.
Patient(S):
Eighty-four women with 3 or more consecutive miscarriages were compared with 69 controls.
Intervention(S):
None.
Main Outcome Measure(S):
Polymerase chain reactions were performed to identify the mutations G1691A in factor V and C677T in MTHFR genes and the polymorphism G20210A in the prothrombin gene.
Result(S):
In women with primary habitual abortions, 27.8% carried the Leiden mutation. No difference was observed in the prevalence of mutation C677T in the MTHFR gene or in polymorphism G20210A in the prothrombin gene.
Conclusion(S):
The Leiden mutation may play a considerable role for women having primary recurrent abortions.