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Modulation of endometrial transforming growth factor beta (TGFbeta) by tamoxifen
P L Carmichael1, J C Pole, P Neven
1Imperial College School of Medicine, Molecular Toxicology, Sir Alexander Fleming Building, South Kensington, SW7 2AZ, London, UK. p.carmichael@ic.ac.uk
Abstract:
Transforming growth factor beta (TGFbeta) immunoreactivity was determined in endometria from non-drug-therapy and tamoxifen-treated patients. Sections were scored for pathology and quantity image analysis performed to determine levels of glandular- or fibrosis-associated TGFbeta1. Tamoxifen-treated patients displayed greater levels of endometrial dysplasia and glandular hyperplasia, in addition to a statistically significant (P<0.0001) elevation in gland-associated TGFbeta1 protein.
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