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Contact sensitization to corticosteroids: increased risk in long term dermatoses
M Corazza1, L Mantovani, C Maranini
1Dipartimento Medicina Clinica e Sperimentale-Sezione Dermatologia, Università degli Studi di Ferrara, Via Savonarola 9, 44100 Ferrara, Italy. czm@unife.it
European Journal of Dermatology : EJD
|November 1, 2000
Summary
Patients with chronic skin conditions frequently develop corticosteroid sensitivity. This study found 13.3% of patients had allergic reactions to corticosteroids, with budesonide being the most common cause.
Area of Science:
- Dermatology
- Allergology
- Contact Dermatitis
Background:
- Chronic dermatoses increase the risk of corticosteroid sensitization.
- Understanding corticosteroid hypersensitivity is crucial for managing long-term skin conditions.
Purpose of the Study:
- To evaluate contact hypersensitivity to corticosteroids in patients with chronic dermatoses.
- To identify common corticosteroid sensitizers in this patient group.
Main Methods:
- Sixty patients with chronic dermatoses underwent patch testing with the Italian GIRDCA series.
- Patients were tested with a specific corticosteroid series and some with their own steroid products.
Main Results:
- Allergic reactions to corticosteroids were observed in 8 out of 60 patients (13.3%).
- Budesonide was the primary sensitizer (7 cases), followed by hydrocortisone-17-butyrate and betamethasone-17-valerate.
- One patient reacted to methylprednisolone aceponate from personal use; 4/8 reactions were linked to prior drug exposure.
Conclusions:
- A high percentage of corticosteroid sensitization exists in patients with chronic dermatoses.
- Budesonide's widespread use may contribute to its high sensitization rate.
- Patch testing with specific corticosteroid series and individual compounds is recommended, especially for unresponsive cases.