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[Spectrum of pneumotropic pathogens in pediatric patients with acute bronchitis and pneumonia]
E A Lykova1, A G Bokovoĭ, V M Bondarenko
1Central Clinical Hospital, Medical Centre of the Managing Department of the President of the Russian Federation, Moscow.
Abstract:
One hundred eighty nine children with acute bronchopulmonary infectious pathological processes were examined bacteriologically and serologically for typical pneumotropic pathogens, 47 of them being as well examined for atypical organisms. Microbial associations mainly with Mycoplasma and Pneumocystis and to a lesser extent with Chlamydia were isolated from the majority of the children. Reactivation of the cytomegalovirus infection was observed in 25 per cent of the children. Pneumonia and bronchitis due to Mycoplasma pneumoniae either as a monoagent or in associations were mainly stated in children over 7 years of age. No significant changes between the indices of the infection due to a definite organism and the active progression of the infectious process of the same etiology were revealed, though in the cases of chlamydiosis the changes reached almost 10 per cent. In cases of acute bronchitis and pneumonia the chlamydial or cytomegalovirus infection could be assumed to be of the persisting nature, mainly acute in cases of pneumococcal infection, mixed in cases of hemophilic or pneumocystic infection, primary contamination with a tendency to prolonged in cases of mycoplasmic infection. The findings of the examination and the clinical and anamnestic data showed that the clinical picture of acute pneumonia had specific features associated with the supposed etiological agents, still it could change under the action of associations of pneumotropic pathogens.
Insights
Pediatric respiratory infections often involve multiple pathogens, including Mycoplasma pneumoniae, Pneumocystis, and Chlamydia. Clinical presentation of pneumonia varies based on the specific infectious agents and their combinations.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Pulmonology
Context:
- Acute bronchopulmonary infections are common in children.
- Bacteriological and serological examinations are crucial for identifying pathogens.
Purpose:
- To investigate the role of typical and atypical pathogens in pediatric acute bronchopulmonary infections.
- To correlate clinical findings with specific etiological agents.
Summary:
- Microbial associations, primarily Mycoplasma, Pneumocystis, and Chlamydia, were identified in most of the 189 children studied.
- Cytomegalovirus reactivation occurred in 25% of cases.
- Mycoplasma pneumoniae was a common cause of pneumonia and bronchitis in children over 7 years old.
- The clinical picture of pneumonia showed variations depending on the etiological agents and their combinations.
Impact:
- Understanding the specific pathogens and their associations aids in diagnosing and managing pediatric respiratory infections.
- This study highlights the complexity of infectious processes in children, emphasizing the need for comprehensive etiological investigations.