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Related Experiment Video

Updated: Jul 20, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Using a multihospital systems framework to evaluate and establish drug use policy.

L C Vermeulen¹, P A Windisch, R J Rydman

¹Center for Drug Policy and Clinical Economics, University of Wisconsin Hospital and Clinics, Madison 53792, USA.

Journal of Medical Systems

|November 1, 2000

Summary

5-hydroxytryptamine subtype-3 (5-HT3) antagonists improved outcomes for chemotherapy patients with high emetic risk. For moderate to low emetic risk, conventional antiemetics were comparable, with granisetron and ondansetron showing similar effectiveness.

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Area of Science:

Oncology
Pharmacology
Clinical Pharmacy

Background:

Antiemetic drug selection is crucial for managing chemotherapy-induced nausea and vomiting (CINV).
Hospital consortiums require evidence-based drug purchasing and use policies.
Comparative effectiveness of different antiemetic classes needs evaluation in real-world settings.

Purpose of the Study:

To evaluate antiemetic use patterns in hospitalized cancer patients receiving chemotherapy.
To assess the comparative effectiveness of granisetron, ondansetron, and conventional antiemetics.
To inform rational drug purchasing and use policies within a hospital consortium.

Main Methods:

Prospective, observational study across 14 academic health centers (Oct-Dec 1994).
Evaluation of antiemetic use in inpatients receiving chemotherapy agents with known emetogenic potential.
Measurement of clinical outcomes including patient functional status and occurrence of vomiting.

Main Results:

5-hydroxytryptamine subtype-3 (5-HT3) antagonists (granisetron, ondansetron) were frequently prescribed.
75% of 439 patients experienced no emesis.
5-HT3 antagonists showed superior outcomes in patients receiving highly emetogenic chemotherapy compared to conventional antiemetics.

Conclusions:

5-HT3 antagonists are associated with better clinical outcomes for highly emetogenic chemotherapy.
Conventional or no antiemetic therapy provides comparable outcomes for moderate/low emetogenic chemotherapy.
Granisetron and ondansetron demonstrated comparable clinical effectiveness.