Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alpha-1-acid glycoprotein.

T Fournier1, N Medjoubi-N, D Porquet

  • 1INSERM U427, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris 5 René Descartes, France.

Biochimica Et Biophysica Acta
|November 4, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergies of THESEUS with the large facilities of the 2030s and guest observer opportunities.

Experimental astronomy·2022
Same author

Placental production of progestins is fully effective in villous cytotrophoblasts and increases with the syncytiotrophoblast formation.

Molecular and cellular endocrinology·2019
Same author

Eating patterns and prevalence of obesity. Lessons learned from the Malaysian Food Barometer.

Appetite·2016
Same author

[Predictive and prognostic factors of preeclampsia: Interest of PlGF and sFLT-1].

Journal de gynecologie, obstetrique et biologie de la reproduction·2016
Same author

Computational Fluid Dynamic Simulations of Maternal Circulation: Wall Shear Stress in the Human Placenta and Its Biological Implications.

PloS one·2016
Same author

Reversibility of superconducting nb weak links driven by the proximity effect in a quantum interference device.

Physical review letters·2015
Same journal

Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

Molecular Basis of Disease Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

General Subjects Cumulative Contents.

Biochimica et biophysica acta·2020
Same journal

Erratum to 'on the role of exchangeable hydrogen bonds for the kinetics of P680<sup>+·</sup> Q<sub>A</sub> <sup>-·</sup> formation and P680<sup>+·</sup> Pheo<sup>-·</sup> recombination in photosystem II' [Biochim. Biophys. Acta 1276 (1996) 35-44].

Biochimica et biophysica acta·2019
Same journal

Oligomeric state of the light-harvesting complexes B800-850 and B875 from purple bacterium Rubrivivax gelatinosus in detergent solution.

Biochimica et biophysica acta·2019
Same journal

Regulation of pigment content and enzyme activity in the cyanobacterium Nostoc sp. Mac grown in continuous light, a light-dark photoperiod, or darkness.

Biochimica et biophysica acta·2019
See all related articles

Alpha-1-acid glycoprotein (AGP) is an acute phase protein that increases during inflammation. Its exact function is unknown, but it binds drugs and has immunomodulatory effects, influenced by its carbohydrate structure.

Area of Science:

  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • Alpha-1-acid glycoprotein (AGP), also known as orosomucoid (ORM), is a major acute phase protein.
  • AGP levels rise during inflammation, infection, or tissue injury, primarily due to increased hepatic synthesis.
  • Its structure includes a peptide chain and extensive glycosylation, with carbohydrate content significantly impacting its properties.

Purpose of the Study:

  • To elucidate the biological function of Alpha-1-acid glycoprotein (AGP).
  • To investigate the immunomodulatory and drug-binding properties of AGP.
  • To explore the role of AGP's carbohydrate composition in its activities.

Main Methods:

  • Analysis of AGP structure and composition.
  • Investigation of AGP's interactions with various drugs.

Related Experiment Videos

  • Utilizing AGP transgenic animal models to study in vivo functionality.

    • Main Results:

    • AGP exhibits significant immunomodulatory effects.
    • AGP possesses the ability to bind a wide range of drugs, both endogenous and exogenous.
    • Both immunomodulatory and binding activities are largely dependent on AGP's carbohydrate structure.

    Conclusions:

    • The precise physiological role of AGP remains to be fully determined.
    • AGP's drug-binding and immunomodulatory functions are critical aspects of its biological activity.
    • AGP transgenic models offer a valuable tool for in vivo functional studies and understanding its physiological significance.