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Mammalian odorant binding proteins.

M Tegoni1, P Pelosi, F Vincent

  • 1Architecture et Fonction des Macromolécules Biologiques, URA 9039-CNRS, IFRI, Marseille, France.

Biochimica Et Biophysica Acta
|November 4, 2000
PubMed
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Odorant binding proteins (OBPs) are abundant in the nose and bind odorants. Their exact physiological role is still hypothetical, despite advances in understanding their structure and biochemistry.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Odorant binding proteins (OBPs) are abundant in the olfactory system.
  • OBPs are lipocalins that reversibly bind odorant molecules.
  • Recent advancements include increased sequence data and two available X-ray structures.

Purpose of the Study:

  • To review current knowledge of OBP biochemistry, sequence, and structure.
  • To examine OBPs in relation to proposed functional hypotheses.
  • To clarify the uncertain physiological role of OBPs.

Main Methods:

  • Analysis of existing protein sequencing data (nasal mucus, DNA).
  • Review of available X-ray crystallographic structures.
  • Biochemical and structural data examination.

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Main Results:

  • Numerous OBP sequences are available.
  • Structural knowledge of OBPs has significantly improved.
  • The physiological role of OBPs remains largely hypothetical.

Conclusions:

  • The function of OBPs is likely not odor transport.
  • Further research is needed to elucidate the precise physiological roles of OBPs.
  • Understanding OBP biochemistry, sequence, and structure is crucial for future functional studies.