Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modern approaches to photoprotection.

H V DeBuys1, S B Levy, J C Murray

  • 1Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

Dermatologic Clinics
|November 4, 2000
PubMed
Summary

Ultraviolet (UV) light causes skin aging and cancer. Current sunscreens protect against UV-B and some UV-A, but not fully against long-wave UV-A, which generates damaging reactive oxygen species.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.

Molecular genetics and genomics : MGG·2026
Same author

Epigenetic Signatures in Monozygotic and Dizygotic Twins Discordant for Orofacial Clefts.

medRxiv : the preprint server for health sciences·2026
Same author

Prognostic score models for acquired resistance to frontline anti-programmed cell death protein 1/programmed death-ligand 1 therapy in metastatic non-small-cell lung cancer.

ESMO real world data and digital oncology·2026
Same author

Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.

medRxiv : the preprint server for health sciences·2025
Same author

Clinical features and outcomes of advanced HER2+ esophageal/GEJ cancer with brain metastasis.

ESMO open·2023
Same author

DNA methylation differences in monozygotic twins with Van der Woude syndrome.

Frontiers in dental medicine·2023

Area of Science:

  • Dermatology
  • Photobiology
  • Biochemistry

Background:

  • Ultraviolet (UV) radiation from sunlight causes significant skin damage, including photoaging and increased risk of skin cancer.
  • Existing sunscreen formulations offer partial protection against UV-B and short-wavelength UV-A radiation.
  • Complete photoprotection, particularly against long-wavelength UV-A, remains a challenge in current sunscreen technology.

Purpose of the Study:

  • To highlight the limitations of current sunscreens in providing comprehensive UV protection.
  • To emphasize the role of long-wavelength UV-A in inducing cellular damage and skin pathologies.
  • To underscore the need for advanced sunscreen strategies targeting the full spectrum of UV radiation.

Main Methods:

  • Review of existing scientific literature on UV radiation effects on skin.

Related Experiment Videos

  • Analysis of the mechanisms by which different UV wavelengths induce cellular damage.
  • Evaluation of the efficacy of current sunscreen filters against UV-A and UV-B radiation.

    • Main Results:

    • UV-B and short-wave UV-A are partially blocked by conventional sunscreens.
    • Long-wave UV-A penetrates deeper into the skin and is highly effective at generating reactive oxygen species (ROS).
    • The generation of ROS by long-wave UV-A is a significant contributor to photoaging and skin carcinogenesis.

    Conclusions:

    • Current sunscreen technology is insufficient for complete protection against the damaging effects of the entire UV spectrum, especially long-wave UV-A.
    • The role of long-wave UV-A in photoaging and skin cancer necessitates the development of novel protective strategies.
    • Further research is crucial for creating advanced sunscreens that offer robust defense against all harmful UV wavelengths.