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Related Experiment Videos

Human ageing and the sympathoadrenal system.

D R Seals1, M D Esler

  • 1Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA. seals@spot.colorado.edu

The Journal of Physiology
|November 4, 2000
PubMed
Summary

Sympathoadrenal function changes with age, showing increased sympathetic nervous system (SNS) activity but reduced adrenaline secretion. Stress response is not exaggerated in older adults, suggesting altered central nervous system (CNS) drive.

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Area of Science:

  • Physiology
  • Neuroscience
  • Gerontology

Background:

  • Sympathoadrenal system function is crucial for stress response and homeostasis.
  • Age-related changes in the sympathoadrenal system are not fully understood.
  • Previous research suggests alterations in sympathetic nervous system (SNS) activity with aging.

Purpose of the Study:

  • To systematically review age-related changes in sympathoadrenal function in healthy adults.
  • To investigate alterations in sympathetic nervous system (SNS) activity and adrenaline secretion with aging.
  • To explore the impact of aging on sympathoadrenal responsiveness to acute stress.

Main Methods:

  • Systematic review of studies over three decades.
  • Utilized neurochemical, neurophysiological, and hemodynamic experimental approaches.

Related Experiment Videos

  • Analysis of tonic and stress-induced sympathoadrenal activity.

    • Main Results:

    • Tonic sympathetic nervous system (SNS) activity increases with age, particularly in skeletal muscle and the gut.
    • Heart's SNS tone increases, partly due to reduced noradrenaline (norepinephrine) reuptake.
    • Tonic adrenaline (epinephrine) secretion decreases with age, masked by reduced plasma clearance.
    • Sympathoadrenal responsiveness to acute stress is not exaggerated; adrenaline release is attenuated in older men.
    • Preliminary data suggest increased subcortical central nervous system (CNS) sympathetic drive.

    Conclusions:

    • Aging leads to increased tonic SNS activity and decreased tonic adrenaline secretion.
    • Sympathoadrenal responsiveness to acute stress is attenuated, not exaggerated, in older adults.
    • Age-associated changes in sympathoadrenal function may impact physiological and pathophysiological processes.