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Endoscopic valvuloplasty for GERD.

T Martinez-Serna1, R E Davis, R Mason

  • 1Departments of Surgery and Preventive Medicine, Creighton University, Omaha, Nebraska, USA.

Gastrointestinal Endoscopy
|November 4, 2000
PubMed
Summary
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Endoscopic sutures below the gastroesophageal junction altered reflux manometry in baboons. This novel approach showed no serious complications, suggesting potential for severe gastroesophageal reflux treatment.

Area of Science:

  • Gastroenterology
  • Minimally Invasive Surgery
  • Endoscopic Procedures

Background:

  • Transoral endoscopic approach proposed for severe gastroesophageal reflux.
  • Procedure avoids cardia mobilization.
  • Optimal suture technique for endoscopic reflux correction remains undefined.

Purpose of the Study:

  • Evaluate suture configurations for endoscopic correction of gastroesophageal reflux.
  • Compare linear vs. circular suture arrangements below the lower esophageal sphincter.

Main Methods:

  • Endoscopic sewing machine used in baboons.
  • Two suture arrangements: linear (Group I) and circular (Group II).
  • Post-procedure evaluation included manometry, barium swallow, endoscopy, and pressure-volume tests over 6 months.

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Main Results:

  • Group II showed increased lower esophageal sphincter length (p=0.010).
  • Group I demonstrated increased lower esophageal sphincter pressure (p=0.008).
  • No reflux, stricture, or esophagitis observed; yield pressure/volume unchanged.

Conclusions:

  • Endoscopic suture placement below the gastroesophageal junction modifies manometric parameters.
  • No significant adverse events were noted.
  • This technique shows promise for managing gastroesophageal reflux disease.