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Related Experiment Videos

Colesevelam hydrochloride: a non-absorbed, polymeric cholesterol-lowering agent.

M H Davidson1, M R Dicklin, K C Maki

  • 1Nutrition and Metabolism Research Unit, Chicago Center for Clinical Research, 515 North State Street, Suite 2700, Chicago, IL 60610, USA. mdavidson@protocare.com

Expert Opinion on Investigational Drugs
|November 4, 2000
PubMed
Summary

Colesevelam hydrochloride is a safe and effective cholesterol-lowering drug that reduces LDL-cholesterol. It offers a non-systemic option for hypercholesterolemia, with good tolerability and minimal side effects, improving compliance.

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Area of Science:

  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Colesevelam hydrochloride (formerly Cholestagel, now WelChol) is a novel polymeric hydrogel.
  • It acts as a potent, water-absorbing agent for cholesterol management.

Purpose of the Study:

  • To evaluate the safety and efficacy of colesevelam hydrochloride as a cholesterol-lowering agent.
  • To assess its lipid-lowering activity in patients with hypercholesterolemia.

Main Methods:

  • Clinical evaluation of colesevelam hydrochloride in approximately 1400 subjects.
  • Dose-dependent assessment of low-density lipoprotein (LDL)-cholesterol reduction.
  • Evaluation of concurrent administration with hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins).

Main Results:

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  • Colesevelam hydrochloride reduced LDL-cholesterol by up to 20% (median) in hypercholesterolemia patients.
  • Effective at once or twice daily dosing; did not affect statin absorption.
  • Combination therapy with statins yielded an additional 8-16% LDL-cholesterol reduction.

Conclusions:

  • Colesevelam hydrochloride is a safe and effective non-systemic agent for hypercholesterolemia.
  • It offers improved tolerability and compliance compared to traditional bile acid sequestrants.
  • Represents a valuable therapeutic option for monotherapy or combination therapy alongside diet and exercise.