Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial dysfunction in the pulmonary vascular bed.

Y F Chen1, S Oparil

  • 1Department of Medicine, University of Alabama at Birmingham 35294-0007, USA.

The American Journal of the Medical Sciences
|November 4, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intensive Blood Pressure Management Preserves Functional Connectivity in Patients with Hypertension from the Systolic Blood Pressure Intervention Randomized Trial.

AJNR. American journal of neuroradiology·2023
Same author

Lowering Albuminuria-Does It Lower the Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Reducing Microalbuminuria-Does It Lower Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Effect of spironolactone on diastolic function in hypertensive left ventricular hypertrophy.

Journal of human hypertension·2014
Same author

Relationships between metrics of visit-to-visit variability of blood pressure.

Journal of human hypertension·2013
Same author

Long-term effects of aldosterone blockade in resistant hypertension associated with chronic kidney disease.

Journal of human hypertension·2011
Same journal

Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

The American journal of the medical sciences·2026
Same journal

In Memoriam: Maurice A. Mufson, MD, MACP.

The American journal of the medical sciences·2026
Same journal

Outcomes of acute myeloid leukemia patients admitted to the intensive care unit within 100 days of allogeneic hematopoietic stem cell transplantation.

The American journal of the medical sciences·2026
Same journal

Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

The American journal of the medical sciences·2026
Same journal

Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

The American journal of the medical sciences·2026
Same journal

The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

The American journal of the medical sciences·2026
See all related articles

Pulmonary endothelial dysfunction, an imbalance of constricting and relaxing factors, contributes to cardiopulmonary diseases. This review focuses on this dysfunction in hypoxia-induced pulmonary hypertension.

Area of Science:

  • Cardiovascular Science
  • Pulmonary Medicine
  • Endothelial Biology

Background:

  • The pulmonary endothelium regulates vascular tone via endothelium-derived constricting factors (EDCF) and endothelium-derived relaxing factors (EDRF).
  • Dysregulation of EDCF and EDRF is implicated in various cardiopulmonary diseases, including pulmonary hypertension and COPD.
  • Pulmonary endothelial dysfunction, characterized by an imbalance between EDCF and EDRF, alters vascular tone in lung diseases.

Purpose of the Study:

  • To review the role of EDCF and EDRF in pulmonary vascular tone regulation.
  • To focus on the mechanisms of pulmonary endothelial dysfunction.
  • To specifically examine the contribution of endothelial dysfunction in hypoxia-induced pulmonary hypertension.

Main Methods:

Related Experiment Videos

  • Literature review of existing research on pulmonary endothelium-derived factors.
  • Analysis of studies investigating EDCF and EDRF in cardiopulmonary diseases.
  • Synthesis of information on hypoxia-induced pulmonary hypertension models.

    • Main Results:

    • Endothelin-1, nitric oxide, prostacyclin, and hyperpolarizing factors are key mediators.
    • Imbalances in these factors are observed in pulmonary hypertension, COPD, and heart failure.
    • Hypoxia significantly impacts the generation and balance of EDCF and EDRF.

    Conclusions:

    • Pulmonary endothelial dysfunction is a critical factor in the pathophysiology of cardiopulmonary diseases.
    • Understanding the EDCF/EDRF balance is crucial for developing treatments for pulmonary hypertension.
    • Further research into hypoxia-induced pulmonary hypertension is warranted.