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Thrombocytopenia associated with octreotide.

K Demirkan1, J F Fleckenstein, T H Self

  • 1Department of Clinical Pharmacy, University of Tennessee, Memphis 38163, USA.

The American Journal of the Medical Sciences
|November 4, 2000
PubMed
Summary

This case report highlights a rare adverse effect of octreotide (Sandostatin), a medication used to treat gastrointestinal bleeding. The study documents octreotide-induced thrombocytopenia, a significant drop in platelet count, confirmed by rechallenge.

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Area of Science:

  • Gastroenterology
  • Hematology
  • Pharmacology

Background:

  • Gastrointestinal bleeding is a serious complication of cirrhosis.
  • Octreotide is commonly used to manage bleeding from esophageal varices.
  • Patient presented with hematemesis and melena secondary to cirrhosis.

Observation:

  • Octreotide therapy was initiated for gastrointestinal bleeding.
  • A significant decrease in platelet count (thrombocytopenia) was observed during octreotide treatment.
  • Platelet count improved upon octreotide discontinuation.

Findings:

  • A second administration of octreotide resulted in a prompt recurrence of thrombocytopenia.
  • This represents the second reported case of octreotide-induced thrombocytopenia.

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  • It is the first documented case of this adverse effect occurring after inadvertent rechallenge.

    • Implications:

    • Clinicians should be aware of the potential for octreotide to cause thrombocytopenia.
    • Monitoring platelet counts during octreotide therapy is crucial, especially in patients with cirrhosis.
    • This case underscores the importance of considering drug-induced adverse effects, even with established treatments.