Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial dysfunction in chronic heart failure: some new basic mechanisms.

T Bachetti1

  • 1Cardiovascular Pathophysiology Research Center, Salvatore Maugeri Foundation, IRCCS, Gussago, BS, Italy. curello@master.cci.unibs.it

Italian Heart Journal : Official Journal of the Italian Federation of Cardiology
|November 4, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinguishable DNA methylation defines a cardiac-specific epigenetic clock.

Clinical epigenetics·2023
Same author

PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma.

International journal of oncology·2008
Same author

Therapeutic modulation of the nitric oxide: all ace inhibitors are not equivalent.

Pharmacological research·2007
Same author

PHOX2B mutations and polyalanine expansions correlate with the severity of the respiratory phenotype and associated symptoms in both congenital and late onset Central Hypoventilation syndrome.

Journal of medical genetics·2004
Same author

[Heart failure: an endothelial disorder?].

Cardiologia (Rome, Italy)·2002
Same author

Chromogranin A in heart failure; a novel neurohumoral factor and a predictor for mortality.

European heart journal·2002
Same journal

Effective method to control catastrophic hemorrhage during redo sternotomy.

Italian heart journal : official journal of the Italian Federation of Cardiology·2006
Same journal

Double aneurysm of the left ventricular wall following cardiac perforation after aortic valvuloplasty.

Italian heart journal : official journal of the Italian Federation of Cardiology·2006
Same journal

Surgical treatment of an aneurysm originating from a Kommerell's diverticulum in the right-sided aortic arch with retroesophageal component.

Italian heart journal : official journal of the Italian Federation of Cardiology·2006
Same journal

A clinical approach for cardiovascular monitoring of HIV-infected patients. Results from an observational cohort study.

Italian heart journal : official journal of the Italian Federation of Cardiology·2006
Same journal

Ectasia of the ascending aorta at the time of aortic valve surgery: replace or relax?

Italian heart journal : official journal of the Italian Federation of Cardiology·2006
Same journal

Evidence for a "gender paradox" in diabetic patients undergoing percutaneous coronary intervention: adverse preprocedural risk but favorable long-term clinical outcome in women.

Italian heart journal : official journal of the Italian Federation of Cardiology·2006
See all related articles

Endothelial dysfunction causes vasoconstriction in chronic heart failure. New factors like nitric oxide pathway issues and endothelin-1 synthesis are key targets for treatment.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Heart Failure Pathophysiology

Background:

  • Endothelial dysfunction is a key factor in chronic heart failure, leading to peripheral vasoconstriction and altered vascular compliance.
  • This dysfunction disrupts the balance between vasodilation and vasoconstriction, impairing necessary blood flow adjustments.

Purpose of the Study:

  • To identify and elucidate the novel factors contributing to endothelial dysfunction in chronic heart failure.
  • To provide a basis for developing targeted therapeutic strategies to restore endothelial function.

Main Methods:

  • Review and synthesis of recent findings on the mechanisms of endothelial dysfunction.
  • Analysis of the L-arginine/nitric oxide pathway, endothelin-1 synthesis, microvessel remodeling, cellular adhesion, and apoptosis.

Related Experiment Videos

Main Results:

  • Identified five key factors contributing to endothelial dysfunction: L-arginine/nitric oxide pathway disturbances, increased endothelin-1 synthesis, microvessel structural remodeling, enhanced adhesion properties, and apoptotic endothelial cell injury.
  • Highlighted the complex interplay among these identified factors.

Conclusions:

  • Understanding the multifaceted nature of endothelial dysfunction is crucial for advancing treatment strategies in chronic heart failure.
  • Targeting these specific pathways offers potential for novel therapeutic interventions to improve vascular function and patient outcomes.