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Identification of a novel taxol-sensitive kinase activity associated with the cytoskeleton
1Department of Pharmaceutical Sciences, University of Southern California School of Pharmacy, Los Angeles, California, 90033, USA.
Biochemical and Biophysical Research Communications
|November 4, 2000
Abstract:
The microtubule-targeted drug, taxol, enhances assembly of alphabeta tubulin dimers into microtubules. Recent work has established that taxol also elicits diverse effects on intracellular signaling. In-gel kinase assays with myelin basic protein as substrate revealed that taxol treatment significantly (P