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Related Experiment Videos

Normal telomere lengths found in cloned cattle.

X C Tian1, J Xu, X Yang

  • 1Department of Animal Science and the Biotechnology Center, University of Connecticut, Storrs, Connecticut USA.

Nature Genetics
|November 4, 2000
PubMed
Summary

Cloned animals may not have shortened telomeres. Research suggests that telomere length in cloned calves derived from fetal cells is comparable to age-matched controls, challenging earlier findings in adult somatic cell clones like Dolly the sheep.

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Area of Science:

  • Reproductive biology
  • Genetics
  • Cell biology

Background:

  • Somatic cell nuclear transfer (SCNT) has enabled cloning in various mammals.
  • Concerns arose regarding 'genetic age' in clones due to shortened telomeres observed in Dolly the sheep.
  • Dolly's telomere shortening was potentially linked to adult donor cell culture.

Purpose of the Study:

  • To investigate telomere length in cloned animals derived from fetal cells.
  • To address the controversy surrounding telomere length in cloned mammals.
  • To determine if shortened telomeres are a general characteristic of cloned animals.

Main Methods:

  • Analysis of telomere length in cloned calves.
  • Comparison of telomere length with age-matched control animals.

Related Experiment Videos

  • Somatic cell nuclear transfer using fetal cells.

    • Main Results:

    • Calves cloned from fetal cells exhibited longer telomeres than previously reported for adult somatic cell clones.
    • Telomere length in fetal-derived clones was comparable to their age-matched controls.
    • Findings challenge the notion that all cloned animals possess shortened telomeres.

    Conclusions:

    • Telomere length in cloned animals may depend on the cell type used for cloning.
    • Cloning from fetal cells does not appear to result in premature aging as indicated by telomere length.
    • The 'genetic age' concerns associated with Dolly the sheep may not be universally applicable to all cloned animals.