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Iron- and aluminum-induced carcinogenesis
L J Anghileri1, F Plenat, E Labouyrie
1Biophysics Laboratory, Faculty of Medicine, University of Nancy, France.
Anticancer Research
|November 4, 2000
Abstract:
Ferric and aluminum complexes with ATP have shown the induction of tumors in the site of subcutaneous injection, whereas sodium ATP has not. A concomitant but apparently independent phenomenon was a severe lymphoadenitis. The tumor calcium concentration showed an inverse relationship with the tumor growth rate. Carcinogenesis and lymphoadenitis are discussed considering well known effects of ferric and aluminum complexes with ATP on the cellular calcium homeostasis and of ATP on lymphatic tissue proliferation.