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Primary spinal epidural mantle cell lymphoma: case report
M Barnard1, B Perez-Ordoñez, D W Rowed
1Department of Anatomic Pathology, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ontario, Canada.
Neurosurgery
|November 4, 2000
Summary
Mantle cell lymphoma, a rare non-Hodgkin's lymphoma, can present as a primary spinal epidural mass. Early diagnosis via histopathology is crucial for this aggressive cancer, necessitating combined-modality treatment.
Area of Science:
- Hematology
- Oncology
- Neurology
Background:
- Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin's lymphoma (NHL) typically diagnosed at advanced stages.
- Spinal epidural involvement is an uncommon manifestation of NHL, usually seen in relapsed or advanced disease.
Observation:
- This report details an extremely rare case of primary spinal epidural mantle cell lymphoma presenting in a 71-year-old male with leg weakness and numbness.
- MRI revealed a lumbosacral spinal epidural mass, confirmed as MCL post-laminectomy and biopsy.
Findings:
- Mantle cell lymphoma presenting as a primary spinal epidural mass is exceptionally rare, with only two prior reports.
- The patient experienced disease recurrence in the maxillary region after initial radiotherapy, with partial response to chemotherapy.
Implications:
- Accurate histopathological examination is vital for diagnosing primary spinal epidural lymphoma and differentiating it from other spinal cord compression causes.
- Given MCL's aggressive nature and poor prognosis, a combined-modality treatment approach is recommended.