Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A man with osteoblastic metastasis and hypocalcaemia.

S C Lim1, C E Tan, T C Aw

  • 1Department of Endocrinology, Singapore General Hospital, Singapore.

Singapore Medical Journal
|November 4, 2000
PubMed
Summary

An 80-year-old man with prostate cancer experienced severe hypocalcaemia and seizures. This case highlights potential vitamin D resistance due to a tumor-secreted factor, requiring high-dose vitamin D therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging the gap in the prevention of respiratory syncytial virus infection among older adults in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Whole-genome and transcriptome analysis enhances precision cancer treatment options.

Annals of oncology : official journal of the European Society for Medical Oncology·2022
Same author

Validity and Reliability of Surface Electromyography Features in Lower Extremity Muscle Contraction in Healthy and Spinal Cord-Injured Participants.

Topics in spinal cord injury rehabilitation·2021
Same author

Predictive Value of the GLIM Criteria in Chinese Community-Dwelling and Institutionalized Older Adults Aged 70 Years and Over.

The journal of nutrition, health & aging·2021
Same author

Laboratory simulation of longitudinally cracked teeth using the step-stress cyclic loading method.

International endodontic journal·2021
Same author

Tumour length as an independent prognostic factor in resectable oesophageal carcinoma.

Annals of the Royal College of Surgeons of England·2019

Area of Science:

  • Endocrinology
  • Oncology
  • Metabolic Bone Disease

Background:

  • Osteoblastic metastases from advanced prostate cancer can lead to complex metabolic disturbances.
  • Severe hypocalcaemia is a rare but critical complication that can manifest with neurological symptoms like seizures.

Observation:

  • An 80-year-old male patient presented with a grand mal seizure attributed to severe hypocalcaemia.
  • Laboratory findings revealed low serum phosphate and ionized calcium, elevated alkaline phosphatase and parathormone, and an unexpectedly high 1,25-dihydroxycholecalciferol level.
  • Bone scan showed findings suggestive of osteomalacia, a condition typically associated with low vitamin D levels.

Findings:

  • The patient's hypocalcaemia persisted despite high-dose calcium supplementation.

Related Experiment Videos

  • Treatment with supraphysiological doses of 1,25-dihydroxyvitamin D3 (calcitriol) effectively improved the biochemical abnormalities.
  • These findings suggest a state of vitamin D resistance potentially mediated by a tumor-derived humoral factor.

    • Implications:

    • This case suggests a paraneoplastic syndrome involving vitamin D resistance in advanced prostate cancer.
    • Understanding this mechanism is crucial for managing metabolic complications in cancer patients.
    • Further research into tumor-secreted factors affecting vitamin D metabolism is warranted.