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Related Experiment Videos

Methodologies for target selection in structural genomics.

M Linial1, G Yona

  • 1Department of Biological Chemistry, Institute of Life Sciences, Hebrew University, 91904, Jerusalem, Israel. michall@leonardo.ls.huji.ac.il

Progress in Biophysics and Molecular Biology
|November 7, 2000
PubMed
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Structural genomics aims to determine protein structures from sequenced genomes. This review covers methods for selecting representative protein targets to maximize the impact of structure determination efforts.

Area of Science:

  • Genomics
  • Structural Biology
  • Bioinformatics

Background:

  • The rapid growth of sequenced genomes reveals vast unexplored protein space.
  • Understanding protein function requires knowledge of their 3D structures.
  • Structural genomics aims to systematically determine protein structures.

Purpose of the Study:

  • To review current strategies in structural genomics for selecting protein targets.
  • To discuss the concept of representative protein structures and folds.
  • To highlight computational methods for identifying novel protein folds.

Main Methods:

  • Review of existing structural genomics methodologies.
  • Analysis of computational techniques for protein fold identification.
  • Discussion of criteria for selecting representative protein targets.

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Main Results:

  • Identification of key approaches for selecting representative protein targets.
  • Elucidation of the concept of representative structures/folds.
  • Overview of computational tools for predicting new structural folds.

Conclusions:

  • Effective target selection is crucial for maximizing the impact of structural genomics.
  • Computational methods are vital for identifying proteins with novel folds.
  • Continued efforts in structural genomics will expand our understanding of the protein universe.